The unifying theme of PROTEO is to understand the relationship between the structure of proteins and their biological functions. PROTEO's work differs from that of other groups in that it is less interested in empirical identification (mapping) and functions, and more interested in how structure affects function and how structural modifications can improve or inhibit the activity of proteins, which are of fundamental importance not only to health, but also to the environment and many other fields. PROTEO must therefore bring together research scientists with complementary areas of expertise; this is a basic requirement when studying large-scale problems in protein science.

Planning and discussion within PROTEO has led to the identification of key programs involving synergy between researchers. Funding will be used to strengthen, improve and renew these programs while cultivating the innovative capacity of members in their respective fields. Given the complementary nature of the researchers' expertise and the likely synergies, the groups research efforts focus on four strategic areas involving the structure-function relationship, where significant breakthroughs are anticipated in the future. In each of these areas, key projects have been launched, based on PROTEO's multidisciplinary environment. For more information, consult the research interests of our members by clicking on the Research Scientists link.


Axis I - Protein-nucleic acid recognition

The interactions between nucleic acids and proteins form the basis of genetic transcription and protein synthesis, both vital processes that are extremely complex and not very well known. Because of their biological and biotechnological importance, it is important to understand the phenomenon of protein nucleic acid recognition and to characterize the protein systems involved.


Axis II - Metalloproteins

Metalloproteins have biological roles and physical properties closely related to the occurrence of one or more metal atoms. Again, studying the structure-function relationship of macromolecules requires specific expertise and equipment. PROTEO researchers have made some important breakthroughs in understanding different metalloproteins, and a number of key multidisciplinary projects have been identified.


Axis III - Membrane proteins and peptides

Biological membranes are sites where transport and signalling phenomena, which are essential to cells, are initiated by specialized proteins either on the surface of or inside the lipid membranes. Membrane proteins are very different from globular proteins, and specific spectroscopic techniques are needed to study them. Over the years, our researchers have developed expertise in specific areas of membrane protein and peptide study. A number of innovative key projects have been identified and are currently being carried out by the centre's researchers.


Axis IV - Protein applications

Proteins are the molecular factories responsible for almost every chemical reaction in an organism. Much of the fundamental research performed by PROTEO is therefore likely to be applied in the industry. We have identified strengths in three target research areas and have established key projects requiring a cooperative approach.